Ishigame Nobufusa served as a bushō from the Sengoku to Azuchi-Momoyama periods.

In 1499, Nobufusa was born as the fourth son of Nanbu Masayasu, the twenty-second head of the Nanbu clan of Mutsu Province.

His older brother, Nanbu Yasunobu, granted him land in Ishigame in Sannohe in the Sannohe District of Mutsu.  Thereafter, he adopted the surname of Ishigame.  His youngest brother, Kemanai Hidenori, also adopted his surname from the place name where he settled.

Nobufusa served as the chamberlain of Kozukata Castle (Morioka Castle) in the Iwate District of Mutsu to defend against the powerful Shiba clan based to the south of the castle.

Nobufusa was succeeded by his eldest son, Ishigame Masayori, a bushi who received a fief of 250 koku in service to the Nanbu domain.  In turn, Masayori’s eldest son, Ishigame Naonori, received a fief of 400 koku and served as a chief retainer of the Nanbu clan.