Honma Ōmi-no-kami served as a bushō during the Sengoku period. He was a retainer of the Yamauchi-Uesugi clan.
Ōmi-no-kami served Uesugi Norimasa, but, owing to prohibitions against deer hunting, he absconded from the clan. At that time, he is said to have been ordered by Nagano Narimsa and others to serve as a spy on the Gohōjō clan. He then served Hōjō Ujimasa but, before long, returned to the Uesugi clan. In 1546, Ōmi-no-kami deployed for the Siege of Kawagoe Castle, but encountered a sudden charge by the Hōjō forces. Despite enabling Norimasa to safely escape, he was killed in action.