Hirate Hisahide served as a bushō during the Sengoku and Azuchi-Momoyama periods.  He was a retainer of the Oda clan of Owari Province.

Hisahide was born as the lineal heir of Hirate Masahide, a retainer of the Oda clan and mentor of Oda Nobunaga in his youth.

Although the authenticity is uncertain, according to genealogical records of the Hirate family, his real name was Masatoshi.  There is also a theory that he was the adopted younger brother of Masahide.

According to the authenticated biography of Nobunaga known as the Shinchō-kōki, he refused to offer as a present a horse coveted by Nobunaga which served as the reason for his father, Masahide, to commit seppuku.  An individual with the common name of Gorōemon is surmised to be Hisahide.  This, however, cannot be confirmed as there are other theories including that Gorōemon was the common name of the oldest brother, Nagamasa, or of an uncle, Noguchi Masatoshi.  Other than possible connections to the individual called Gorōemon, Hisahide may have been the same individual as other sons of Masahide known under the common names of Kenmotsu and Jinzaemon, or these may have referred to Hisahide’s son (or younger brother), Hirohide.

Hisahide obeyed Nobunaga and fought in numerous battles.  In 1574, during the battle to pacify Ise Province known as the Nagashima Ikkō-ikki, he was killed in action.  Meanwhile, his youngest brother (or his son), Hirate Hirohide, died the year before at the Battle of Mikatagahara so the bloodline of the Hirate clan came to an end.