Hachinohe Masayoshi served as a bushō from the Sengoku to early Edo periods.  He was a retainer of the Sannohe-Nanbu clan.  Masayoshi was the eighteenth head of the Hachinohe clan.  In the early Edo period he served as the chief elder of the Mutsu-Morioka domain.

In 1543, Masayoshi was born as the son of Niida Yukimasa from an illegitimate branch of the Hachinohe clan.  Later, he was adopted by Hachinohe Katsuyoshi, the seventeenth head of the Hachinohe clan.

After the death of Nanbu Harumasa (who had raised the stature of the Sannohe-Nanbu clan to become the main branch of the Nanbu family), his eldest son and successor, Nanbu Harutsugu, suddenly died, giving rise to a succession struggle.  Masayoshi then backed Nanbu Nobunao as the successor.  At this time, Masayoshi was also a member of the Nanbu clan and received support to become the head of the clan, but was persuaded by Kita Nobuchika to decline the role.  Thereafter, Masayoshi served as a close associate of Nobunao.

In 1590, at the Conquest of Odawara, he advised Nobunao to serve under Toyotomi Hideyoshi.  Masayoshi himself was entrusted by Nobunao to defend Sannohe Castle.  Owing to an eye ailment, he became blind.

He died in 1610.