Rokkaku Masataka served as a bushō and shugo daimyō during the late-Muromachi period.  He was the military governor of Ōmi Province.

Masataka was born as the son of Rokkaku Tokitsuna.

In 1456, after Masataka’s uncle, Rokkaku Hisayori, died in a fit of anger, he was succeeded by his younger cousin, Kamejumaru (Rokkaku Takayori or Rokkaku Masayori).  Masataka served as the guardian of this successor.  In 1458, Kamejumaru was ousted by the Muromachi bakufu and Masataka was appointed as the military governor of Ōmi and became the head of the Rokkaku clan.  Two years later, in 1460, Masataka murdered the son of Iba Mitsutaka, the deputy military governor of Ōmi.  As a result, Masataka was removed from the line of succession and the headship of the clan reverted to Kamejumaru.

In 1467, after the outbreak of the Ōnin-Bunmei War, Kamejumaru sided with the Western Army.  Masataka was solicited by the Eastern Army and, together with Kyōgoku Katsuhide, toppled the base of the Rokkaku clan at Kannonji Castle in Ōmi.  He was then reappointed by the Eastern Army to serve as the military governor of Ōmi.  In 1469, when Kamejumaru departed from Kyōto and headed out to recapture Kannonji Castle, the Eastern Army removed Masataka from his position and appointed Kyōgoku Mochikiyo, the father of Katsuhide, as the military governor of Ōmi.

In 1470, Mochikiyo died.  Katsuhide died before Mochihide so, within the Kyōgoku clan, a succession struggle erupted between Kyōgoku Masatsune, the third son who backed by Kyōgoku Magodōjimaru (the lineal grandson of Mochikiyo) and the second son, Kyōgoku Masamitsu, who supported Kyōgoku Takakiyo.  This conflict is known as the Kyōgoku Disturbance.  Divisions between those aligning with either the Eastern Army or the Western Army weakened the Kyōgoku clan.  Masataka, together with Masatsune, remained with the Eastern Army and came into conflict with Masamitsu, Takakiyo, and Kamejumaru who defected to the Western Army.  In 1471, after the death of Magodōjimaru, Masataka was appointed as the military governor of Ōmi for the third time but, in the tenth month, was defeated by Kamejumaru and died in battle.

Thereafter, his adopted son, Torayasha, was appointed as the military governor of Ōmi but was caught-up in the Kyōgoku Disturbance.  In 1473, the role was forcibly taken away by Masatsune.  One more adopted son, Torachiyo, was appointed by the Muromachi bakufu as the military governor after Rokkaku Takayori fled from Ōmi during the Chōkyō-Entoku Expedition in 1492.  In 1493, Ashikaga Yoshiki, the tenth shōgun of the Muromachi bakufu, was ousted in a coup d’ètat orchestrated by Hosokawa Masamoto, the kanrei, or deputy shōgun.  This is known as the Meiō Political Incident and resulted in the fall from power of Takayori’s patron, Ashikaga Yoshiki, after which he fell into ruin.  Sassa Narimasa is said to have been a descendant of Masataka.