Andō Kiyosue served as a sengoku daimyō of Dewa Province during the Sengoku period. He was the seventh head of the Hiyama branch of the Andō family.
In 1514, Kiyosue was born as the son of Andō Hirosue and was the father of Andō Chikasue. He resided in Hiyama Castle in Dewa. Kiyosue received as his formal wife the daughter of Andō Takasue. Takasue was a sengoku daimyō and the seventh head of the Minato-Andō who had been in conflict with the Hiyama-Andō since the time of Andō Akisue in the late Muromachi period. This marriage came out of a reconciliation between these two branches of the Andō clan.
Kiyosue is surmised by some researchers to have been involved in the First Minato Disturbance in 1544 between the Hiyama and Minato branches of the Andō. Moreover, he strengthened the governance of the Andō over the Kakizaki clan in the Ezo territory which encompassed areas north of the main island of Honshū including Hokkaidō, the Sakhalin Islands, the Kuril Islands, and other surrounding islands, touring the territory himself. At this time, Kiyosue mediated an end to the disputes between the Kakizaki clan and the Ainu people that had persisted for one hundred years and had them sign a trade accord.
According to records of the Matsumae domain, in 1550, Kiyosue visited the Ezo territory. In his presence, Kakizaki Suehiro of Matsumae Castle, Chikomotain, the tribal chief of the Ezo people based in Shiriuchi, and Hashitain, the tribal chief of the Ezo people in Setanai, reconciled and the two tribal chiefs were recognized as the leaders with jurisdiction over the eastern and western peoples in the territories and control over travel from the Ezo territory to Matsumae. Furthermore, Hashitain was to reside in Kaminokuni in the southwestern portion of Hokkaidō while Kiyosue would allocate to each of the tribal chiefs a portion of the taxes on trade with the Yamato people.
Meanwhile, a decision was then made to take steps for trading vessels of the Ainu people to travel to and from Matsumae.
In general, during the Sengoku period, the Ezo territories were outside the control of the Andō clan while the Kakizaki clan operated autonomously, but, based on these details, there is a recognition that the Andō clan exercised a certain degree of authority in this region.