Isonome Hidekane served as a bushō during the Sengoku period. He was a retainer of the Hiyama-Andō clan and served as the lord of Sunasawa Castle in Dewa Province. His early name was Fujiwara Hidemori. He also used the name of Shirōemon.
Hidekane was a direct retainer of Andō Chikasue, a sengoku daimyō of Dewa. In 1582, when Asari Katsuyori revolted, he later entered the base of the Asari at Ōdate Castle as a representative of Chikasue in the Hinai District.
In 1588, upon orders of Akita Sanesue, he was assigned to govern the Hachirōgata region, where he built Sunasawa Castle (also known as Gojōme Castle). At this time, he adopted the surname of Isonome based on the name of the location.
That same year, however, he had a falling out with Sanesue, whereupon he colluded with Nanbu Nobunao and brought the Nanbu clan into the Hinai District. Kita Nobuchika, a retainer of the Nanbu clan, entered Ōdate Castle as a chamberlain.