Honjō Tokinaga served as a bushō during the Sengoku period.
Tokinaga was born as the son of Honjō Fusanaga (Mikawa-no-kami). He had four sons and was the grandfather of Honjō Shigenaga.
Tokinaga served as the head of the Honjō who were members of the Chibu party in the Agakita Group. He is known for constructing Honjō Castle atop Mount Gagyū.
In the eighth month of 1507, Nagao Tamekage (the deputy military governor of Echigo) overthrew Uesugi Fusayoshi (the military governor of Echigo) who killed himself in the midst of fleeing after an attack on his residence. This was an example of the phenomenon in the Sengoku period of gekokujō by which persons of lower rank usurped those above them. Tamekage then backed Fusayoshi’s adopted son, Uesugi Sadazane, to serve as the next military governor. Sadazane, however, was a puppet of Tamekage. These events occurred in the context of a series of battles across the Kantō and Hokuriku regions during the Eishō era (1504 to 1521) known as the Eishō Conflict.
Meanwhile, Tokinaga, along with members of the Takenomata and Irobe clans, mounted a resistance against Tamekage. These allies, however, were subsequently attacked by Nakajō Fujisuke and Tsukiji Tadamoto who were aligned with Tamekage. Honjō Castle was toppled and Tokinaga surrendered. Thereafter, he was confined to Sarusawa Castle, an outlying castle for the main base of Honjō Castle. He died shortly thereafter. During this battle, Tokinaga’s eldest son, Honjō Yajirō, was killed in action so Tokinaga was succeeded by his second son, Honjō Fusanaga (Yamato-no-kami).