Dōke Masahide served as a bushō during the Sengoku period. Dōke was a nephew of Takigawa Kazumasu, a senior retainer of Oda Nobunaga.
The Dōke clan served on behalf of the Kōmyōbu Temple in Kyōto as administrators of shōen, or manors, located in Owari, Mino, and Mikawa provinces. From the Kamakura to Sengoku periods, however, each of these manors was encroached upon and came under the control of local powers.
Masahide served Takigawa Kazumasu and, in the third month of 1582, in the wake of the demise of the Kai-Takeda clan, Kazumasu was granted control of the Saku and Chiisagata districts in eastern Shinano along with the entire province of Kōzuke. Masahide was entrusted with a fief of 20,000 koku in the Saku District and became the chamberlain of Komoro Castle.
On 6/2 of Tenshō 10 (1582), Oda Nobunaga unexpectedly died in a coup d’état known as the Honnō Temple Incident in Kyōto. On 6/6, Masahide received news of the event while at Komoro Castle. On 6/7, Kazumasu was informed at Maebashi Castle in Kōzuke. The death of Nobunaga triggered an uprising by former retainers of the Takeda clan in Kai. On 6/18, Mori Yoshinari left Matsushiro Castle in northern Shinano Province and went to Mino Province while, on that same day, Kawajiri Hidetaka, a retainer of Nobunaga appointed as the lord of Kai Province after the fall of the Takeda, was murdered by former retainers of the Takeda.
Meanwhile, Hōjō Ujinao of Sagami Province set into motion his army in the Kantō and, on 6/16, attacked Kuragano in Kōzuke. Kazumasu aimed to intercept the invading forces, but, on 6/19, was defeated at the Battle of Kannagawa. He then abandoned Kōzuke and, on 6/21, led over 2,000 soldiers to Masahide’s base at Komoro Castle. After tendering hostages from the kunishū of the Saku and Chiisagata districts to Kiso Yoshimasa, Kazumasu was permitted safe passage to Kisodani. Yoshimasa was a former retainer of the Takeda who switched his allegiance to Nobunaga several months prior to the fall of the Takeda. On 6/27, together with Masahide, he departed from Komoro Castle. At this time, Kazumasu ordered Masahide to transfer Komoro Castle to Yoda Nobushige. On 6/28, they arrived at Shimosuwa and received a written reply from Yoshimasa permitting them to travel through the area. On 7/1, Kazumasu returned to his base at Ise-Nagashima.
Masahide’s son, Dōke Chōzaemon, served a relative, Nakamura Kazutada, a daimyō and the head of the Yonago domain in Hōki Province.