Andō Akisue served as a bushō from the late Muromachi to Sengoku periods. Akisue served as the fourth head of the Minato-Andō of Dewa Province.
The genealogical records of the Andō clan contain many different accounts. In particular, with respect to the Minato family, the descendants ceased so the records are confusing. There are many individuals with the same name as their ancestors, in addition to many name changes and the mixing together of their exploits. Among the heads of the Minato family over the generations, Akisue can only be confirmed from secondary sources. The existence of primary sources of information has not been confirmed either from shrines, temples, or other locations.
Akisue was born as the son of Andō Koresue. Koresue solicited Andō Masasue from the main branch of the family (who had been driven out of his base in Tsugaru by the Nanbu clan) and, in 1456, had him establish a base on Shōroku Island in Akita and decimate a kokujin, or provincial landowner, named Kasai Hidekiyo. Operating under the command of the Nanbu, Hidekiyo had governed the Kawakita area of Akita. Koresue had Masasue establish a main base in Hiyama. Masasue, however, endeavored to expand his power with the aim of recovering Tsugaru. In the era of Akisue, this led to a power-struggle between the Hiyama-Andō and the Minato-Andō families in regard to military conscription and the Oga Peninsula.