Toki Yoritsugu served as a bushō during the Azuchi-Momoyama period and a hatamoto during the early Edo period.

Yoritsugu was born as the second son of Toki Yoriaki, the shugo daimyō of Mino Province.

Owing to slander by a retainer named Saitō Toshimasa (Dōsan), his older brother, Toki Yorihide incurred the wrath of his father and was removed from the line of succession so Yoritsugu became the designated successor to the clan.

Together with his father, Yoritsugu moved to Kawate Castle and then Ōga Castle.  In 1547, when his father was ousted from Mino, a young Yoritsugu moved to Kyōto.

During the conflict between Dōsan and Saitō Tatsuoki, Yoritsugu sided with Yoshitsugu and received official recognition of his rights to his landholdings from Yoritsugu.

Thereafter, he headed toward Yamato Province and turned for support to Matsunaga Hisahide of Tamonyama Castle.

In 1587, he served as a member of the umamawari, or cavalry division, for Toyotomi Hideyoshi and was granted a fief of 500 koku in the Furuichi District of Kawachi Province.

In 1600, after the Battle of Sekigahara, Yoritsugu met Tokugawa Ieyasu and Tokugawa Hidetada and received official recognition of his rights to his landholdings.  Ieyasu gave a precious sword from the Heian period known as shishiō to Yoritsugu on the grounds that the Toki clan were descendants of Minamoto no Yorimasa, a noble and bushō from the same period.  The sword had been confiscated from Saimura Masahiro, a daimyō from Tajima Province who committed seppuku after being defeat as a member of the Western Army at the Battle of Sekigahara.  This sword is kept at the Tōkyō National Musuem and designated an Important Cultural Asset.

Thereafter, Yoritsugu served as a hatamoto, or direct retainer of the Edo bakufu.

On 11/10 of Keichō 19 (1614), Yoritsugu died in Fushimi in Yamashiro Province.  He was seventy years old.