Uesugi Akizane served as a bushō during the Sengoku period. Akizane was the twelfth head of the Yamanouchi-Uesugi family and served as the deputy shōgun of the Kantō.
Akizane was born as the second son of Ashikaga Shigeuji, the Koga kubō. Initially, he adopted the name of Yoshitsuna, but, later, after his adoption by Uesugi Akisada, changed his name to Uesugi Akizane.
In 1510, after the death of Akisada at the Battle of Nagamorihara, Akizane inherited the Yamanouchi-Uesugi family, but came into conflict with another adoptee of Akisada, Uesugi Norifusa. Akizane requested support from his natural older brother, Ashikaga Masauji (the Koga kubō), but Norifusa allied with Masauji’s son, Ashikaga Takamoto, and resisted. This led to a division of the Kantō.
Akizane, with the support of Nagao Akikata and Narita Akiyasu, was based in Hachigata Castle in the Ōsato District of Musashi Province. In 1512, he was attacked by Yokose Kageshige and Nagao Kagenaga backed by Norifusa and was defeated, losing his authority. This occurred in connection with the Eishō Conflict.
Akizane received assistance from Masauji to flee but, before long, died of illness.