Sena Ujisada served as a bushō during the Sengoku period.  Ujisada was the second head of the Sena clan descended from the Tōtōmi-Imagawa clan.

Initially, Ujisada resided in Futamata Castle in Tōtōmi Province and, later, resided in the village of Sena in the Ihara District of Suruga Province.

In 1536, during the Hanakura Conflict, a succession struggle between Sengaku Shōhō (Imagawa Yoshimoto) and Genkō Etan, Ujisada sided with Shōhō.

Ujisada died on 3/16 of Tenbun 7 (1538).  He was forty-two years old.

Based on genealogical records, Ujisada had three sons and one daughter including Sena Ujitoshi (lineal heir), Sena Yoshihiro (second son, later known as Sekiguchi Chikanaga, father of Tsukiyama-dono), Ujitsugu (third son, also known as Jinjūrō), and a daughter (wife of Takeda Zaemon-no-jō).