Sakuma Morishige (Daigaku) served as a bushō during the Sengoku period.  He was a retainer of the Oda clan.  He was commonly known as Sakuma Daigaku.

Morishige served as a retainer of the Oda clan from the era of Oda Nobuhide, a sengoku daimyō in Owari Province.  He appears to have become a chief retainer of Oda Nobuyuki (Nobukatsu), the younger brother of Nobunaga.  In 1551, during the funeral for Nobuhide, he accompanied Nobuyuki.

In 1556, during the conflict between Nobunaga and Nobuyuki, Morishige joined Sakuma Nobumori in support of Nobunaga.  To prepare for an attack by Shibata Katsuie and Hayashi Hidesada who supported Nobuyuki, he was positioned in the Nazuka fortress.  At the Battle of Inō, he firmly held the fortress and killed Hashimoto Jūzō (who was fighting for Nobuyuki) during its defense.

In 1560, at the Battle of Okehazama, during a preliminary skirmish, he was assigned in the fifth month to the Marune fortress.  Together with Washizu fortress nearby, the men were responsible for containing Ōdaka Castle, a key base for the invasion of Owari by the Imagawa clan of Suruga Province.  Owing to an attack led by Matsudaira Motoyasu (later known as Tokugawa Ieyasu) who came as reinforcements in support of the Imagawa at Ōdaka Castle, on 5/18, Marune fortress fell and Morishige was killed in action.  There are no records of him thereafter.

Morishige’s son, Okuyama Moriaki, changed his surname from Sakuma to Okuyama associated with the Okuyama manor in Echigo Province where his ancestors resided.  Moriaki served Niwa Nagahide and, later, Toyotomi Hideyoshi.  His daughters wed Shinjō Naoyori and Sakuma Morimasa.