Ōta Sukeyori served as a bushō during the Sengoku period.

In 1484, Sukeyori was born as the son of Ōta Sukeie.  He had the common name of Hikoroku and the title of Mino-no-kami, or Governor of Mino.

Sukeyori served the Ōgigayatsu-Uesugi family, but, in the second month of 1524 (in the wake of the Battle of Takanawahara Castle), he abandoned them in favor of Hōjō Ujitsuna and attacked Iwatsuki Castle in the Saitama District of Musashi Province.  The lord of the castle, Shibue Uemon Taifu, was killed in the battle.  In the seventh month of the same year, following an attack on Iwatsuki Castle by the Kai-Takeda army serving as reinforcements for the Ōgigayatsu-Uesugi, the occupants surrendered and the castle reverted to the control of the Ōgigayatsu-Uesugi.

Based on historical records, the Ōta first took control of Iwatsuki Castle in 1524.  According to another theory, the Ōta captured the castle in the second month of 1522.  Meanwhile, Ōta Eigen (Bitchū-no-kami), who appeared to be a cousin or older brother of Sukeyori and lineal heir of the Ōta is believed to have taken over the clan, while Sukeyori had his daughter wed Eigen’s son named Genroku.  During the Daiei era (1521 to 1528), the end of Eigen’s lineage led to the emergence of Sukeyori’s lineage.

Hōjō Ujitsuna responded by backing Shibue Saburō from the Shibue family previously serving as the lords of Iwatsuki Castle and attacked.  In the second month of 1525, after the death in battle of approximately 3,000 soldiers, Iwatsuki Castle fell and Sukeyori retreated to Ishido Castle in the Adachi District of Musashi Province.  In the ninth month of 1531, he killed Shibue Saburō en route to recapturing Iwatsuki Castle.  Ishido Castle was located near the Yōchiku Temple in the township of Mionoya in the Hiki District of Musashi built by his father, Ōta Sukeie, along with Kawagoe Castle, so it is surmised that this territory was controlled by the Ōta from around the time of Sukeie.

In 1533, Sukeyori retired and transferred the headship of the clan to his son and heir, Ōta Sukeaki.  On 4/20 of Tenbun 5 (1536), Sukeyori died at the age of fifty-three.  Based on the date in the Buddhist mortuary tablet for Sukeyori in the Yōchiku Temple, there is a theory that Sukeyori killed himself out of resentment that his son, Sukeaki, sided with the Hōjō clan during the Siege of Kawagoe Castle occurring on 4/20 of Tenbun 15 (1546).