Ōida Kagekuni served as a bushō during the Sengoku and Azuchi-Momoyama periods.  He was a retainer of the Uesugi clan.

Kagekuni was born as the son of Nagao Fusanaga, the sixth head of the Ueda-Nagao family.

The Ōida clan, who maintained close relations with the Ueda-Nagao clan at the time, did not have a son so Kagekuni was received as the adopted son-in-law of Ōida Ujikage, the head of the clan.  The Ōida were descended from the Satomi clan of the Nitta lineage of the Seiwa-Genji.

Thereafter, Kagekuni served Uesugi Kenshin, followed by his nephew, Uesugi Kagekatsu.  In 1590, Kagekuni was suddenly ordered by Kagekatsu to commit seppuku.  His son, Motomasa, was turned over to another family while the Ōida clan were removed from their position as retainers.

Shimakura Toshitsugu (whose mother was from the Ōida clan) inherited the family name and continued as a retainer of the Yonezawa domain in the Edo period.