Niiro Yasuhisa served as a bushō during the Sengoku period.  He was a retainer of the Shimazu clan of Satsuma Province.

Yasuhisa was born as the son of Niiro Tadazumi from an illegitimate branch of the Niiro clan.

From an early age, he served Shimazu Tadayoshi and, upon orders of Tadayoshi, was raised by Anraku Utanosuke, Ikoma Chikuzen-no-suke, and a woman named Daini.  After reaching adulthood, he became a chief retainer of Tadayoshi.  In 1539, Yasuhisa participated in an assault against Kaseda Castle, the base of Ōyama Kuranosuke, a bushō aligned with Shimazu Sanehisa of the Sasshū-Shimazu branch of the family who was opposed to Tadayoshi.  In 1542, during an insurrection by Tanegashima Shigetoki and his son, Tanegashima Tokitaka, Yasuhisa was dispatched as a messenger upon orders of Shimazu Takahisa.

In 1548, Yasuhisa was assigned in lieu of Ijūin Tadaaki to Ichiki-Tsurumaru Castle in Satsuma.

In 1549, a Jesuit missionary from Spain named Francisco de Xavier came to Kagoshima and visited Tsurumaru Castle in the course of conducting his evangelical mission.  Yasuhisa warmly received the visitors, permitting them to freely engage in promoting their religion.  At this time, Yasuhisa’s wife, his sons (Niiro Hisaatsu and Niiro Ryōan), and seventeen retainers were baptized.  In 1561, upon the invitation of Shimazu Takahisa, a Portuguese merchant named Luís de Almeida paid a visit to Tsurumaru Castle while traveling through Kagoshima.  On this occasion, seventy individuals received baptismal rites.

The year of his demise is uncertain, but it occurred on 8/2 from illness.