Nasu Sukezane served as a bushō from the late Muromachi to Sengoku periods.  Sukezane was the sixteenth head of the Nasu clan and the lord of Karasuyama Castle in the Nasu District of Shimotsuke Province.

Sukezane was born as the son of Nasu Sukemochi, the head of the Lower Nasu family.  Conflict with the Upper Nasu family persisted but, in 1472, through mediation by Yūki Naotomo of the Shirakawa-Yūki clan, he wed the daughter of Nasu Akisuke, the head of the Upper Nasu family and endeavored to improve relations between the two families.  That same year, Sukezane collaborated with Yūki Ujihiro and Chiba Noritane to enable the return to Koga of Ashikaga Shigeuji, the Koga kubō, after he was earlier expelled from Koga Castle.

From 1492 until his demise, he oversaw the expansion and renovation of Karasuyama Castle.

Sukezane died in 1494.  His son, Nasu Sukefusa, inherited the headship of the clan.