Makabe Fusamoto served as a bushō during the Azuchi-Momoyama and early Edo periods. He was a retainer of the Satake clan and, in the Edo period, a senior retainer of the Kubota (Akita) domain in Dewa Province.
In 1569, Fusamoto was born as the eldest son of Makabe Yoshimoto, a retainer of the Satake clan of Hitachi Province. Yoshimoto’s older brother, Makabe Ujimoto, did not have a natural heir so he adopted Fusamoto to become his designated heir. In 1592, during the Bunroku Campaign on the Korean Peninsula, Fusamoto served on behalf of his adoptive father. Around 1596, he became the nineteenth head of the Makabe clan.
Later, he was transferred to Kakioka Castle in Hitachi, but, after the Battle of Sekigahara in 1600, he followed the Satake upon their transfer to Akita in Dewa Province, becoming the chamberlain of Kakunodate Castle with a fief of 1,500 koku.
In 1612, Fusamoto died of illness. He did not have a natural son so his younger brother, Makabe Shigemoto, became his adopted heir, succeeding him as the twentieth head of the Makabe clan.
A black gate said to have been donated by Fusamoto still remains at the Rakuhō Temple in the city of Sakuragawa in Ibaraki Prefecture.