Ohama Yoshitaka served as a hatamoto, or direct retainer of the Edo bakufu, during the early Edo period.

Yoshitaka was born as the son of Ohama Mitsutaka.  His formal wife was the daughter of Makino Nobunari.  His common name was Hisatarō or Minbe-no-jō.  His younger brother was named Ohama Naotaka (a retainer of the Tōdō clan).  His children included a daughter (the second wife of Kinoshita Nobuyoshi), Ohama Naotaka (Tomotaka), Ohama Hirotaka, and Ohama Yoshitaka (the adopted son of Ohama Shigetaka).

Yoshitaka joined his father at the Winter Campaign of Ōsaka.  In 1640, he became the head of maritime operations, and, in 1642, the head of maritime operations for Ōsaka.  He was skillful at munitions, established a training center in Sakai and gave instruction to disciples.