Kakizaki Haruie served as a bushō during the Sengoku and Azuchi-Momoyama periods.  He was a retainer of the Uesugi clan and served as the lord of Kakizaki Castle.  He had the common name of Heizaburō.

Haruie was born as the second son of Kakizaki Kageie, a senior retainer of Uesugi Kenshin, the sengoku daimyō of Echigo Province.

On 3/5 of Eiroku 13 (1570), when Kenshin and Hōjō Ujiyasu executed an alliance known as the Etsusō dōmei, or the Alliance between Echigo and Sagami, Haruie was tendered as a hostage to the Hōjō clan because Kenshin had no children.  After the demise of Ujiyasu, the alliance was scrapped and Haruie returned to his father, Kageie.  In 1574, following the death of Kageie, Haruie inherited the headship of the clan.  According to records of military service in the Uesugi family from 1575, Haruie was in charge of 260 troops.

In 1578, the death of Kenshin gave rise to a succession dispute between Uesugi Kagekatsu and Uesugi Kagetora known as the Otate Conflict.  Owing to his support for Kagetora, Haruie was killed at Kasugayama Castle.  However, a faction of retainers led by Ueno Kuhei-no-jō backing his son, Chikumamaru (later known as Kakizaki Noriie), joined the side of Kagekatsu so the Kakizaki family led by Chikumamaru continued to exist.

There is also a theory that, in 1577, Haruie was scorned by Kenshin for colluding with the Oda and murdered.