Higuchi Masakane served as a bushō from the Sengoku to early Edo periods.
Masakane originated from Hōki Province and is surmised to have served in the army of Hashiba Hideyoshi during the Invasion of Chūgoku.
At the Battle of Sekigahara, he joined the Western Army so, after their defeat, became a rōnin, or wandering samurai.
In 1614, during the Battle of Kizugawaguchi in the opening stages of the Winter Campaign of the Siege of Ōsaka, he intercepted the navy of Hachisuka Yoshishige.
In 1615, after the fall of Ōsaka Castle in the Summer Campaign of the Siege of Ōsaka, he turned for support to Horio Tadaharu.
Masakane died in 1619.