Yura Sadashige served as a bushō during the Azuchi-Momoyama period and hatamoto during the early Edo period.  Sadashige served as the second head of the Yura family.

In 1574, Sadashige was born as the son of Yura Kunishige.  In 1590, during the Conquest of Odawara by Toyotomi Hideyoshi, Sadashige’s father, Kunishige, came under pressure from the Hōjō clan and was forced to hole-up in Odawara Castle.  His grandmother, Myōin-ni, had Sadashige serve as the commander-in-chief of a contingent of 200 soldiers to serve in the division of Maeda Toshiie for an assault on Matsuida Castle in Kōzuke Province.

Owing to these contributions, Myōin-ni received 5,000 koku in Ushiku in Hitachi Province and the Yura family narrowly avoided elimination.  Kunishige inherited the landholdings that were officially recognized by the Toyotomi administration.

Thereafter, Sadashige served Tokugawa Ieyasu, and, in 1600, at the Battle of Sekigahara, he deployed as a member of the division led by Nagai Naokatsu.   During the Siege of Ōsaka, he served under Doi Toshikatsu but, in the Summer Campaign in 1615, was injured in the Battle of Shiginoguchi.

Throughout the Edo period, his descendants served in the role of kōke, a role in the Edo bakufu with responsibility for conducting ceremonies and rituals.