Yamanaka Mitsuyuki served as a bushō during the Sengoku period.  He was a retainer of the Amago clan.

In 1520, Mitsuyuki was born as the son of Yamanaka Katsushige or Yamanaka Sadayuki, retainers of the Amago clan, the sengoku daimyō of Izumo Province.

Mitsuyuki served Amago Tsunehisa and Amago Haruhisa.  On 9/20 of Tenbun 15 (1546), he died at the age of twenty-seven.

According to the genealogical chart of the Kōnoike family, he was born in 1509, he succeeded his father as the lord of Shiraga Castle.  He inherited 4,000 kan and adopted the name of Yamanaka Hyōbu-Taifu.  He was known for being smart and courageous, but, on 8/7 of Tenbun 13 (1544), he preceded his father, Yamanaka Sadayuki, in death at the age of thirty-six.  Details other than his posthumous Buddhist name are unknown.

In one source, there are no references to the founder of the Izumo-Yamanaka clan, Yamanaka Yukihisa.  This gave rise to a theory that rather than descending from the Uta-Genji, the Izumo-Yamanaka originated from the Ōmi-Yamanaka (of the Tachibana surname) by accompanying the Amago clan when they departed the capital.  The existence of Mitsuyuki himself is questioned.