Ujiie Sadanao served as a bushō during the Sengoku period. He was a retainer of the Mogami clan.
At his coming-of-age ceremony, he received a character from the name of Mogami Yoshisada and adopted the name of Sadanao. In 1520, after the death of Yoshisada, he served Mogami Yoshimori, the adopted son of Yoshisada who succeeded Yoshisada.
In 1542, during the Tenbun Conflict, he supported Yoshimori (who was still young at the time) while participating in battle on behalf of Date Tanemune. The conflict ended with a victory for Date Harumune (Tanemune’s son) but Sadanao endeavored to restore relations between Harumune and Yoshmori. In 1570, during a succession struggle between Yoshimori and Mogami Yoshiaki (his eldest son) known as the Tenshō Mogami Conflict, despite his weak constitution, Sadanao mediated a settlement between the father and son, enabling a transfer of headship of the clan to Yoshiaki.
He died soon thereafter and was succeeded by his eldest son and designated heir, Ujiie Morimune.