Ujii Sukemoto served as a bushō during the Sengoku and Azuchi-Momoyama periods.

The Ujii clan, a branch of the Nagano-Kudō clan,  were kokujin, or provincial landowners, in Ise Province.

Sukemoto was born as the son of Nagano Tanefuji (the fourteenth head of the Nagano-Kudō clan) and succeeded to the Ujii clan, a cadet family.  As a consequence of the invasion of Ise by Oda Nobunaga, in the second month of 1568, the Nagano-Kudō clan adopted Oda Nobukane (the younger brother of Nobunaga).  Sukemoto acknowledged this adoption and agreed to serve as a retainer of the Oda.  Thereafter, he approached Nobunaga in an effort to enable a continuation of the Ujii clan, but, owing to differences with Nobukane, in 1580, he was dispossessed of his base at Ujii Castle and ousted.

As a result, he turned to his son-in-law, Yabe Iesada, for assistance, and, through this connection, was allowed to serve as a direct retainer of Nobunaga, albeit for a small stipend.  After the death of Nobunaga, he returned to Ise.  In 1584, at the Battle of Komaki-Nagakute, he fought on the side of Hashiba Hideyoshi.

Sukemoto’s son, Sukemitsu (Hyōbu-taifu) was the son-in-law of Takigawa Kazumasu.  After wandering several provinces, he was brought in to serve under Toyotomi Hideyoshi.