Uesugi Kagenobu served as a bushō during the Sengoku period.
Kagenobu originated from the Suyoshi-Nagao family who were members of the Nagao clan serving as the deputy military governors of Echigo Province. It appears that he inherited the family name of the Jōjō-Uesugi family who were one of the branches of the Uesugi clan serving as the military governors of Echigo. Based on historical accounts, an individual from around the middle of the sixteenth century known as Etchi-no-jūrō is surmised to have referred to Kagenobu.
Kagenobu is deemed to have been the grandson of Nagao Akiyoshi (Kagetaka), the father of the mother (Seigan-in) of Uesugi Kenshin. After Kagenobu inherited the Jōjō-Uesugi family, Akiyoshi adopted the name of Jōjō Nyūdō. Under another theory, Sanponji Hidekage (the younger brother of Sanponji Kagesada) was his father, but Kagesada also originated from the Nagao clan so, in any event, he appears to have been a member of the Nagao clan.
The name of Jūrō appears on a statement of military rules jointly signed by kokujin, or provincial landowners, in Echigo in the first month of 1531. Jūrō was the common name of Uesugi Kiyokata, a bushō from the mid-Muromachi period who served as the first head of the Jōjō-Uesugi family so, if this name referred to Kagenobu, then it is surmised that he inherited the Jōjō-Uesugi family by this time. In the tenth month of 1559, an individual named Etchi-no-Jūrō-dono presented a long sword to Uesugi Masatora (Kenshin) to celebrate his return to Kyōto, which may have referred to Kagenobu. According to genealogical records of the Uesugi family, Kagenobu’s family adopted the Uesugi surname from the era of his son, Nobutora.
The timing is uncertain, but, around 1573, it appears that Kagenobu transferred the headship of the family to his son, Uesugi Nobutora. Thereafter, Nobutora served Uesugi Kenshin and Uesugi Kagetora, but died during the succession struggle within the Uesugi clan known as the Otate Conflict. This extinguished the name of the Uesugi-Jūrō family. The vestiges were granted to Kagenobu’s son-in-law, Honjō Shigenaga.