Ueno Yorihisa served as a bushō during the Sengoku period.  He was the lord of Matsuyama Castle in Bitchū Province.

The Bitchū-Ueno were an illegitimate branch of the Ueno clan who, in turn, were a branch of the Ashikaga clan descended from the Kawachi-Genji.

In 1493, Ashikaga Yoshitane, the tenth shōgun of the Muromachi bakufu, was deposed in a coup orchestrated by the deputy shōgun, Hosokawa Masamoto, and replaced by his younger cousin, Ashikaga Yoshizumi.  This is known as the Meiō Political Incident.  Yoshitane then fled to the western provinces but in 1508 reclaimed his position as the shōgun.  In 1509, he assigned Ueno Nobutaka to Kimurasan Castle in Bitchū to solidify control of the province.

Later, Nobutaka entrusted Kimurasan Castle to a family member, Ueno Takanao, and Matsuyama Castle to Yorihisa, and then returned to the capital.  Yorihisa endeavored to expand his influence in Bitchū and, later, transferred Matsuyama Castle to his lineal heir, Ueno Yoriuji.  He then assigned his second son, Uemon-no-jō, to Omatsuyama Castle to further strengthen his base of power in the province.

During the Eishō era (1504 to 1520), Yorihisa rebuilt the Tenchūsan-Ankoku Temple.  After a later visit by a daimyō named Kobori Masakazu, the temple was renamed in honor of Yorihisa to the Yorihisa Temple which remains to this day.