Uchida Sanehisa served as a bushō from the Sengoku to early Edo periods.  He was a retainer of the Akizuki clan and served as a chief retainer of the Hyūga-Takanabe domain.

In 1559, Akizuki Tanezane of Chikuzen Province was defeated by Ōtomo Yoshishige (Sōrin) and, through the assistance of the Mōri clan, fled to Suō Province.  At this time, Sanehisa’s older brother, Uchida Iki-no-kami, provided a residence to Tanezane.  On 9/3 of Eiroku 10 (1567), Sanehisa commanded reinforcements from the Mōri in support of Tanezane to recover his former territory at the Battle of Yasumimatsu.  Thereafter, Sanehisa served as a veteran bushō of the Akizuki clan and he was appointed as the lord of 左右良岳 Castle (Matera Castle) in Chikuzen.

In 1588, as an outcome of the Pacification of Kyūshū by Toyotomi Hideyoshi, the Akizuki clan was moved to the town of Takanabe in the Koyu District of Hyūga Province.  At this time, Sanehisa received 500 koku for his retirement and he worked to rebuild Taka Castle in Niiroin in the eastern portion of the Koyu District which had been decimated during the war.

In 1617, Sanehisa died at the age of eighty.  The headship of the clan was inherited by his eldest son, Hikotarō.  In 1587, Hikotarō was killed in action during the Siege of Iwaya Castle.  He was succeeded by Sanehisa’s second son, Uchida Shirōemon.