Ishigame Masayori served as a bushi during the Sengoku and Azuchi-Momoyama periods.

Masayori was born as the eldest son and designated heir of Ishigame Nobufusa.

The Ishigame were an illegitimate branch of the Nanbu clan.  His father, Nobufusa, was a landowner in Ishigame in Sannohe in the Sannohe District of Mutsu Province so he adopted the surname of Ishigame.

After the demise of his father, Masayori inherited the headship of the clan.  As a retainer of the Nanbu domain, Masayori received a fief of 250 koku.  He died in 1593.

His son, Ishigame Naonori, was awarded a fief of 400 koku and served as a chief retainer of the Nanbu clan.