The Battle of Ishigasegawa occurred three times over the period from Eiroku 1 (1558) to Eiroku 4 (1561).  The clashes occurred on the shores of the Ishigase River in Owari Province.

Over a period of years prior to this battle, Oda Nobunaga had largely consolidated power in his home province of Owari; however, during the early years of the Eiroku era (1558 to 1570), Imagawa Yoshimoto, the sengoku daimyō of neighboring Suruga Province, encroached on territory in Owari.  From 1558 to 1561, the Oda army, with support from Mizuno Nobumoto, fought against the Imagawa forces supported by Matsudaira Motoyasu (later known as Tokugawa Ieyasu) across the Ishigase River.  These clashes did not result in a decisive victory for either side of the battle.

In the fifth month of 1560, after Yoshimoto was killed in a lightening attack by the Oda army at the Battle of Okehazama, the Oda and Mizuno clans reconciled with Motoyasu.  Thereafter, Nobunaga remained an ally of Motoyasu (Ieyasu) for over two decades until the demise of Nobunaga in 1582.